| Date | Location | Result | |
| Nov 12, 2010 | Fort Wayne, Ind. | Aquinas 3, Madonna 0 (25-19,25-12,25-14) | Box score |
| Nov 04, 2010 | Grand Rapids, Mich. | Madonna 3, Cornerstone 0 (25-18,25-8,25-21) | Box score |
| Nov 02, 2010 | Grand Rapids, Mich. | Aquinas 3, Madonna 1 (25-17,25-17,17-25,25-21) | Box score |
| Oct 29, 2010 | Livonia, Mich. | Madonna 3, Concordia 0 (25-10,25-10,25-13) | Box score |
| Oct 26, 2010 | Livonia, Mich, | Madonna 3, Siena Heights 0 (25-22,25-19,25-15) | Box score |
| Oct 23, 2010 | Livonia, Mich. | Madonna 3, Bellevue 1 (25-17,25-22,21-25,25-22) | Box score |
| Oct 23, 2010 | Livonia, Mich. | Madonna 3, Rochester 0 (25-9,25-9,25-16) | Box score |
| Oct 22, 2010 | Livonia, Mich. | Columbia 3, Madonna 1 (25-21,15-25,25-21,25-12) | Box score |
| Oct 22, 2010 | Livonia, Mich. | Madonna 3, Ashford 0 (25-19,25-19,25-18) | Box score |
| Oct 21, 2010 | Lima, Ohio | Madonna 3, Northwestern Ohio 2 (19-25,21-25,25-17,25-18,15-9) | Box score |
| Oct 19, 2010 | Livonia, Mich. | Madonna 3, Davenport 0 (25-21,25-21,25-18) | Box score |
| Oct 16, 2010 | Yorktown, Ind. | Madonna 3, Calumet St. Joseph 0 (25-11,25-7,25-2) | Box score |
| Oct 16, 2010 | Yorktown, Ind. | Madonna 3, Indiana East 1 (19-25,25-21,25-17,25-22) | Box score |
| Oct 15, 2010 | Yorktown, Ind. | Madonna 3, Indiana Southeast 0 (25-16,25-18,25-18) | Box score |
| Oct 15, 2010 | Yorktown, Ind. | Madonna 3, Illinois Tech 0 (25-20,25-17,25-19) | Box score |
| Oct 14, 2010 | Ft. Wayne, Ind. | Madonna 3, Indiana Tech 1 (19-25,25-19,25-19,25-21) | Box score |
| Oct 08, 2010 | Livonia, Mich. | Madonna 3, Lourdes 0 (25-16,25-11,25-16) | Box score |
| Oct 07, 2010 | Dearborn, Mich. | Madonna 3, Michigan-Dearborn 0 (25-16,25-21,25-15) | Box score |
| Oct 05, 2010 | Adrian, Mich. | Madonna 3, Siena Heights 0 (25-14,25-12,25-19) | Box score |
| Sep 30, 2010 | Grand Rapids, Mich. | Madonna 3, Davenport 0 (25-18,25-16,25-17) | Box score |
| Sep 28, 2010 | Livonia, Mich. | Madonna 3, Northwestern Ohio 1 (20-25,25-17,25-18,25-12) | Box score |
| Sep 24, 2010 | Livonia, Mich. | Madonna 3, Michigan-Dearborn 0 (25-15,25-13,25-11) | Box score |
| Sep 23, 2010 | Livonia, Mich. | Madonna 3, Cornerstone 0 (25-21,25-23,25-18) | Box score |
| Sep 21, 2010 | Livonia, Mich. | Madonna 3, Aquinas 1 (21-25,25-17,25-18,25-20) | Box score |
| Sep 16, 2010 | Ann Arbor, Mich. | Madonna 3, Concordia 0 (25-13,25-9,25-14) | Box score |
| Sep 14, 2010 | Livonia, Mich. | Indiana Tech 3, Madonna 2 (25-22,16-25,18-25,25-12,16-14) | Box score |
| Sep 11, 2010 | Livonia, Mich. | Madonna 3, Michigan-Dearborn 0 (25-14,25-12,25-14) | Box score |
| Sep 11, 2010 | Livonia, Mich. | Madonna 3, Windsor 0 (25-11,25-12,25-17) | Box score |
| Sep 10, 2010 | Livonia, Mich. | Madonna 3, Rochester 0 (25-14,25-7,25-18) | Box score |
| Sep 10, 2010 | Livonia, Mich. | Madonna 3, Davenport 1 (25-13,22-25,25-19,25-18) | Box score |
| Sep 04, 2010 | Daytona Beach, Fla. | Wayland Baptist 3, Madonna 2 (19-25,25-16,25-18,13-25,15-13) | Box score |
| Sep 04, 2010 | Daytona Beach, Fla. | Lewis-Clark State 3, Madonna 2 (22-25,25-27,27-25,25-22,15-12) | Box score |
| Sep 03, 2010 | Daytona Beach, Fla. | Embry-Riddle 3, Madonna 0 (25-13,25-20,25-23) | Box score |
| Sep 03, 2010 | Daytona Beach, Fla. | Oklahoma Baptist 3, Madonna 1 (25-20,19-25,25-18,25-22) | Box score |
| Aug 28, 2010 | Dearborn, Mich. | Georgetown 3, Madonna 2 (20-25,25-18,25-21,16-25,15-10) | Box score |
| Aug 28, 2010 | Dearborn, Mich. | Madonna 3, Notre Dame 0 (25-20,25-12,25-17) | Box score |
| Aug 27, 2010 | Dearborn, Mich. | Madonna 3, Bethel 1 (21-25,25-23,25-11,25-21) | Box score |
| Aug 27, 2010 | Dearborn, Mich. | Madonna 3, Spring Arbor 1 (25-9,20-25,25-18,25-23) | Box score |